Abstract: Transgenic plant vaccines, or plant-based vaccines, are edible biological products generated in plants via genetic engineering.To create transgenic plant vaccines, genetic techniques introduce antigens into selected plants.When plant-based vaccines are consumed, the host initiates a mucosal immune response against the antigen synthesized in the plant and becomes immune to the pathogen from which the antigen was taken.The main advantages of transgenic plant vaccines lie in ease of production (utilizing energy from the Sun) and their availability to economically challenged countries as a relatively inexpensive form of vaccination for infectious diseases that can be produced with local agricultural implementation.Plant vaccines have been tested in animals and have been shown to generate significant levels of protective antibodies following one or more oral doses.The possibility of development of plant allergies and the development of immunological tolerance to pathogen proteins synthesized in plants are potential concerns that need to be addressed through continued research